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MIDDLE = METAPHASE. What happens during Anaphase? Mitosis or Meiosis? The process of nuclear division in cells during which the number of chromosomes per cell is reduced by half through the separation of homologous chromosomes.Meiosis is the process by which a haploid cell is formed from a diploid cell. The difference between haploid cells and diploid cells is that haploid cells contain one complete set of chromosomes, whereas diploid cells contain two complete sets of chromosomes. Meiosis involves the division of a diploid (2n) parent cell.